Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent manner.

Only when contact inhibition and serum deprivation were used together a modest increase in miR-223 expression was appreciated, although it did not reach statistical significance (Figure 1B and Supplementary Table 5 ). p27 is a critical mediator of miR-223 expression after contact inhibition Next, we investigated in more detail the regulation of miR-223 by p27 in G1 arrested cells following contact inhibition.

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