Basal gene expression by lung CD4+ T cells in chronic obstructive pulmonary disease identifies independent molecular correlates of airflow obstruction and emphysema extent.

Spearman non-parametric analysis found highly significant positive correlations with several analytes, including IFN-γ ( r = 0.57, p = 0.0009), GATA-3 ( r = 0.51, p = 0.004), CTLA-4 ( r = 0.48; p = 0.006), FOXP3 ( r = 0.37, p = 0.04), and an inverse correlation with CCL2 ( r = −0.62, p = 0.0003) (data not shown).

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Conversely, production of CCL2 was significantly augmented in the COPD subjects, and CCL3 showed a trend towards increased production, which did not attain statistical significance ( Fig. 1B, 1C ) .

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Despite considerable overlap, we found that subjects in Group A had a significantly decreased FEV 1% predicted, as well as a lower FEV 1 /FVC ratio that just failed to attain significance, relative to all subjects in Group B ( Fig. 5A, 5B ).

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