Skeletal development of mice lacking bone sialoprotein (BSP)--impairment of long bone growth and progressive establishment of high trabecular bone mass.

PLoS One · 2014 · PMC4015893 · PMID 24816232

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Our QRT-PCR analysis in early post-natal (6 days) mice found that IHH expression was surprisingly increased in the BSP−/−, despite the thinner hypertrophic zone, while PTHrP actually showed a trend to reduction, suggesting a disruption of the feedback loop.

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