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Wen-dan decoction improves negative emotions in sleep-deprived rats by regulating orexin-a and leptin expression.

Evid Based Complement Alternat Med · 2014 · PMC4016855 · PMID 24864160

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After long-term SD, significantly decreased protein expression of orexin-A was observed in prefrontal cortex and hypothalamus, but mRNA expression of orexin-A in prefrontal cortex and hypothalamus of the model group was lower than the control group, though this latter difference did not reach statistical significance.

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