In the North America, CRC incidence and mortality showed a trend towards declining ( 7 ) and its mortality in the European Union was also decreasing ( 30 ), however in eastern Europe an increasing incidence and mortality has been registered ( 31 ).
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The declining trend of pancreatic cancer mortality in Iran is in contrast to western countries such as Germany, US, France and Spain which have reported an increasing trend according to WHO Mortality Database ( 45 ).