Unlike the first trimester, second trimester uNK cells demonstrated trends of dose-dependent increases in the secretion of angiogenin, Ang-2, TIMP-1, ICAM-1 and VEGF-A, which just failed to reach statistical significance (overall effect of T3: P = 0.077; Fig. 3 B).
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Triiodothyronine regulates angiogenic growth factor and cytokine secretion by isolated human decidual cells in a cell-type specific and gestational age-dependent manner.
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0.0770
0.0770
The sentences
Thus, we conclude that the effect of decidual cell-conditioned media on EVT invasion is largely independent of the initial T3 added. When we compared the invasiveness of EVT treated with conditioned media from total decidual cells with media collected from cell-free wells, there appeared to be an overall trend towards increased invasion although this did not reach statistical significance ( P = 0.3; Fig. 7 A).