Transient receptor potential ankyrin 1 receptor activation in vitro and in vivo by pro-tussive agents: GRC 17536 as a promising anti-tussive therapeutic.

Although the citric acid response pattern and the maximum Ca +2 influx response observed in these three cell types are different, the responsiveness to citric acid stimulus in the form of increased Ca +2 influx was a clear trend displayed by these TRPA1 expressing cell types, unlike the lack of any significant response seen with the hTRPV1 expressing CHO cell line (data not shown).

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