In an NSCLC model (H1975, EGFR T790M), combinations of afatinib with a MEK inhibitor ( PD032901 ), a SRC inhibitor (dasatinib) or a PI3K inhibitor (PI-103) showed additive effects on induction of apoptosis, although this did not reach statistical significance (Sos et al. 2010 ).
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A comprehensive review of the preclinical efficacy profile of the ErbB family blocker afatinib in cancer.
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