Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance.

Thus the MM, WW and GW mice increased their β cell mass by 3.2‐, 3.4‐, and 1.8‐fold, respectively, after 12 months on a high fat diet ( Figure 6a ) and did not differ, although the GW mice showed a trend for somewhat decreased β cell mass relative to MM and WW mice. β cell replication and apoptosis in the pancreata of the MM, WW and GW mice were assessed by immunostaining for the Ki67 antigen and activated caspase‐3 ( Figure 6b and c ).

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