Obesity may attenuate the HbA1c-lowering effect of sitagliptin in Japanese type 2 diabetic patients.

Similarly, our analysis showed that the reductions in HbA1c after 12 weeks treatment tended to be greater for patients on 50 mg sitagliptin compared with those on 25 mg sitagliptin (0.64% vs 0.59%, respectively), although the difference failed to reach statistical significance ( P = 0.70) and disappeared entirely on multiple linear regression analysis ( P = 0.94).

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