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Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease.

Mol Neurodegener · 2014 · PMC4028006 · PMID 24885175

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The increased p25:p35 ratio observed in D257A; APP/Ld mice compared to APP/Ld did not reach statistical significance but further corroborated the observed neurodegeneration in D257A; APP/Ld mice.

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