Deficient spontaneous in vitro apoptosis and increased tmTNF reverse signaling-induced apoptosis of monocytes predict suboptimal therapeutic response of rheumatoid arthritis to TNF inhibition.

Parallel analysis of SIA and of tmTNF RSA at baseline showed a highly significant inverse correlation between the two parameters ( P = 0.0075, R = -0.5791, Figure 4 A,B).

also in 132,142 other papers

For IL-1sRII, a significant negative correlation of the concentrations induced by tmTNF RS with the reduction in the DAS28 after 12 weeks was detected (Figure 3 D), whereas a similar trend for IL-1sRI did not reach statistical significance ( R = -0.333; P = 0.177).

also in 111,027 other papers