Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas.

Concentrations of 5-HIAA and the 5-HIAA:5-HT ratio were elevated in CRFR2-null mice under baseline conditions within the caudal subregion of the DRN (DRC), and these effects approached significance in the adjacent dorsal subregion (DRD).

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Increased sensitivity of structures throughout the forebrain to 5-HT 2 R agonists and to 5-HT 1A R in some limbic structures in CRFR2-null mice suggests that postsynaptic receptor responsiveness is increased, and thus the latter mechanism may be significant.

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