Combination therapy with an anti-IL-1β antibody and GAD65 DNA vaccine can reverse recent-onset diabetes in the RIP-GP mouse model.

Diabetes · 2014 · PMC4030110 · PMID 24520125

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did not reach statistical significanceno p-value reported

This difference did not reach statistical significance, suggesting that monotherapy based upon IL-1β blockade was inefficacious in the rapid-onset RIP-GP mouse model, paralleling the recent clinical trial experience ( 17 ).

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