NgR2 −/− mice seemed to have reduced basal ACTH (NgR2 +/+ = 100.0 ± 38%, NgR2 −/− = 37.8 ± 9.4%) and corticosterone (NgR2 +/+ = 100.0 ± 33%, NgR2 −/− = 52.7 ± 14.2%) concentrations compared to NgR2 +/+ , but due to high variability, this did not reach statistical significance (ACTH: t = 1.66, p = 0.12; CORT: t = 1.32, p = 0.21; Figure 4 ).
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Loss of Nogo receptor homolog NgR2 alters spine morphology of CA1 neurons and emotionality in adult mice.
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