Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia.

However, when patient samples were divided into the 10 most sensitive (0 - 53% viability of control) and 10 least sensitive (95 - above 100% viability of control) to nutlin-3, the least sensitive patient samples showed a trend towards higher expression levels of most heat shock proteins, although the differences in median values were not significant (median values for sensitive versus non-sensitive samples for Hsp27(pSer82): 7.9/7.8 u/ml; Hsp27(pSer15): 5.8/6.1 u/ml; Hsp90 alpha: 10.8/12.0 ng/ml; Hsp40: 14.6/21.9 ng/ml; Hsp70: 42.9/58.7 ng/ml; Hsp60: 262.1/245.1 ng/ml) (Figure 4 B) (for AML patient characteristics, see Additional file 3 ).

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