Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders.

Nominally significant responder by genotype effects ( Figure 2 ) were noted for the dopamine receptors DRD1 rs5326 ( P =0.006, Figure 2a ) and rs4867798 ( P <0.05, Figure 2b ), DRD3 ser9gly rs6280 ( P <0.05, Figure 2c ) and DRD4 rs11246226 ( P <0.04, Figure 2d ); the adrenergic receptor ADRA2A rs1800544 ( P <0.02, Figure 2e ); the dopamine and serotonin transporters SLC6A3 VNTR ( P <0.05, Figure 2f ) and SLC6A4 STin2 VNTR ( P <0.05, Figure 2g ), respectively; and the catabolic enzyme COMT val/met rs4680 ( P <0.05, Figure 2h ).

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