showed a trendP = 0.062
Recognition of at least 1 of the citrullinated peptides analyzed showed a trend toward an association with arthritis development (hazard ratio [HR] 4.2, 95% CI 0.9–18.6, P = 0.062), and the total number of citrullinated peptides recognized was significantly associated with arthritis development (HR 1.2, 95% CI 1.0–1.4, P = 0.012).