Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC Class II-dependent manner.

Flow cytometric analysis of total cNT preparations from mice treated with the 3 groups (n = 4 mice per group) however, revealed few overall changes in immune cell percentages, although a significant decrease in the dendritic cell (DC) (CD11c + ) population was revealed in the wild-type MGAS8232 infected animals compared with MGAS8232 ΔSAg infect mice, and the analysis also showed a trend for increased neutrophils (GR1 + ) in wild-type MGAS8232 infected animals ( Figure S1 ) that was consistent with the histological analyses.

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