HLA-DRB1*08:02 Is Associated with Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis Patients.

Biomark Insights · 2014 · PMC4038630 · PMID 24899791

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP = 1.09 × 10 −6actually significant

RESULTS AND CONCLUSION This preliminary study showed a highly significant association of DRB1*08:02 with BI-Pro ( P = 1.09 × 10 −6 , corrected P [ Pc ] = 1.96 × 10 −5 , odds ratio [OR] 25.17, 95% confidence interval [CI] 7.98–79.38).

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did not reach statistical significanceno p-value reported

The difference did not reach statistical significance, because the strong linkage disequilibrium between DRB1*08:02 and DQB1*04:02 causes low frequency of DRB1*08:02 in the patients without DQB1*04:02 and that of DQB1*04:02 in the patients without DRB1*08:02 .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.