Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice.

The phosphorylation level of tau at other epitopes studied (Thr181, Ser199, Thr205, Thr231, and ser422) was also lower in the insulin-treated group than the untreated group, but the decreases did not reach statistical significance ( Figure 4C ).

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