Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries.

However, a nominally significant association was revealed at rs16952725 of FTO in males ( P -value = 6.87×10 −4 for BMI and P -value = 8.55×10 −3 for FM), but not in the female specific sample ( P -value = 0.55 for BMI and P -value = 0.43 for FM) ( Table 3 ).

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Although the impact of environmental factors is likely to be significant, many studies have shown that body weight and obesity are strongly influenced by genetic factors, with heritability estimates often in excess of 50% particularly when derived from comparisons of identical and fraternal twins [4] , [5] .

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For the other five genes, 26 SNPs, 11 SNPs and 33 SNPs from CTNNBL1, PPARG and LEPR showed marginal significance of associations with P -values ranging between 1.50×10 −3 and 4.94×10 −2 (Results not shown).

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In non-Caucasian populations, we only found marginally significant associations.

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