A recent Brazilian study of leukemia in children younger than 2 years found a statistically significant increase in adjusted odds ratios of 1.66 for infants with ALL and a near-significant increase of 1.54 for AML when any second-degree relative had cancer, supporting the conclusion of more subtle familial genetic susceptibility in IL. 32 Interestingly, the odds ratios increased significantly when the children's father had any cancer (1.80 ALL and 2.34 AML), but no such significant increase was observed when mothers had cancer.
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Excess congenital non-synonymous variation in leukemia-associated genes in MLL- infant leukemia: a Children's Oncology Group report.
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