The reduced rearing activity in our Irp2 −/− mice is consistent with a slight reduction in self-grooming (which could imply a reduction in vertical locomotion), although this did not reach statistical significance, and is similar to other Irp2 −/− mice that exhibited a significant reduction in self-grooming activity [17] , [26] .
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Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments.
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