d normal thyroid females, there was myocardial hypoperfusion and increased intima media thickness in SCH females which suggest it as cardiovascular disease (CVD) risk.[ 43 ] In a meta-analysis involving 25,977 participants out of which 2,020 were with SCH (seven prospective cohort studies) revealed a significant trend of increased risk of coronary heart disease (CHD) events at higher serum TSH concentrations.[ 44 ] This increased risk was not affected based on gender, age, or presence of preexisting CVD.
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