A genetically-encoded YFP sensor with enhanced chloride sensitivity, photostability and reduced ph interference demonstrates augmented transmembrane chloride movement by gerbil prestin (SLC26a5).

Although the differences in individual mean fluorescence did not reach statistical significance, the rates of change per extracellular Cl − were significantly different (slope difference: 0.02 unit/100 mM Cl − ; p<0.05), and indicates a more rapid transmembrane flux of Cl − with prestin when extracellular Cl − increases.

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