Most of the UPR markers were elevated in P23H-1 retinae treated with arimoclomol compared with vehicle but did not reach statistical significance; however, there was a significant increase in phosphorylated eIF2 α ( Figures 6a–c and Supplementary Figure S2 ).
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The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa.
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