ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS.

Cell Death Dis · 2014 · PMC4047920 · PMID 24832597

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a clear trendno p-value reported

Compared with untreated control (mean neurite length per cell: 1825±96 μ m) and the control virus AAV.EGFP-shRNA (2144±189 μ m), there was, however, a clear trend toward longer neurites in the cells transduced with AAV.ROCK2-shRNA (2614±212 μ m) and AAV.LIMK1-shRNA (2530±224 μ m).

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