Increased vascular invasion score is associated with hormone receptor negative tumors Seven of the data sets had information on ER-status [8] – [11] , [13] – [15] , and six of the sets showed significant correlations between high signature score and ER-negative tumors, five of them highly significant (p<0.001).
For recurrence free survival, data set GSE1456 showed a borderline significance for the signature score, with HR of 1.9, p = 0.063, and in data set GSE20685 vascular invasion signature score is an independent prognostic marker for recurrence free survival with HR = 1.8, p = 0.01.
A high signature score was associated with reduced recurrence free survival in three data sets, whereas the fourth data set showed a trend between reduced recurrence free survival and high signature score (p = 0.079) ( Figure 3 ).
Two of them showed a significant correlation between high signature score and HER2-positive tumors, one data set had a borderline significant association, and two data sets did not show any significant association between the signature score and HER2-status ( Table 3 ).