Disease progression model for Clinical Dementia Rating-Sum of Boxes in mild cognitive impairment and Alzheimer's subjects from the Alzheimer's Disease Neuroimaging Initiative.

Subject’s baseline age was also assessed as a covariate in the missing data model, but it did not reach statistical significance ( P =0.4).

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Secondly, a separate residual error parameter was tested for progressors vs nonprogressors, and it was found that the residual error for nonprogressors was greater than that for progressors (the OFV decreased by 34 points, which is highly significant).

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