Whereas the total amount of deposited collagen showed a trend towards increase in Grade 1A–B compared with Grade 0, no differences were seen in Grade 3 compared with Grade 0 EMBs, suggesting that the increased collagen expression might be counterbalanced by extensive proteolytic degradation in Grade 3 rejecting EMBs ( Supplementary material online, Figure S5 ).
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Matricellular proteins and matrix metalloproteinases mark the inflammatory and fibrotic response in human cardiac allograft rejection.
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