Interaction effects of long-term air pollution exposure and variants in the GSTP1, GSTT1 and GSTCD genes on risk of acute myocardial infarction and hypertension: a case-control study.

[29] In the present study, less obvious air pollution effect variation by genotype was suggested for GSTP1 rs596603 and the GSTT1 null variant, where air pollution exposure was associated with a higher and nominally significant risk of AMI in subjects with GT or TT genotype in GSTP1 rs596603 vs GG (OR 2.12, 95% CI 1.09–4.10 vs OR 1.40, 95% CIs 0.73–2.68), as well as for individuals carrying the non-null genotype of GSTT1 , i.e. the presence of a coding gene, compared to subjects with the null genotype (OR 2.02, 95% CI 1.13–3.60 vs OR 1.40, 95% CI 0.33–5.96).

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