As far as TIC signatures are concerned, GSEA comparison of the HIS with three published TIC signatures [ 36 , 84 , 85 ] showed a trend for anti-correlation between our signature and the tumor-initiating gene profile (that is, genes that are upregulated in TICs are significantly enriched in the downregulated genes of the HIS, whereas genes that are downregulated in TICs are significantly enriched in the upregulated genes of the HIS (see Additional File 9 )).
← all excerpts
Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients.
1
—
—