Parenteral glutamine supplementation in critical illness: a systematic review.

In addition, parenteral GLN was associated with a strong trend towards a reduction in infectious complications (RR 0.86, 95% CI 0.73, 1.02, P = 0.09) and ICU length of stay (LOS) (WMD –1.91, (95% CI -4.10, 0.28, P = 0.09) and significant reduction in hospital LOS (WMD -2.56, 95% CI -4.71, -0.42, P = 0.02).

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With regard to infectious morbidity, this earlier meta-analysis showed a stronger statistically significant reduction of infectious morbidity (RR = 0.83; 95% CI, 0.72 to 0.95) compared to our data where a nonsignificant trend of similar magnitude for a benefit on infection was observed (RR 0.86, 95% CI 0.73, 1.02).

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