Also, since tele and proximal enhancers share similar functions (for example, both these enhancer types play a role in heart development and heart morphogenesis), display common cardiac TF binding motifs (such as those of MEF2A) and exhibit common selective features (both of them are highly conserved as compared to controls), it could be expected that the evolutionary constraint difference between tele and proximal enhancers is only weakly significant ( P -values are between 0.001 and 0.05) in almost all cases.
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Genome-wide analysis of functional and evolutionary features of tele-enhancers.
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