Modulation of pro-inflammatory activation of monocytes and dendritic cells by aza-bis-phosphonate dendrimer as an experimental therapeutic agent.

This is strongly in favor of an anti-inflammatory activity.In monocytes, a decrease of the IL-12:IL-10 ratio in the presence of dendrimer was observed but did not reach statistical significance although donors with the highest initial IL-12:IL-10 ratios were the ones which were the most affected by dendrimer ABP (Figure 4 A).

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