The nuclear progesterone receptor reduces post-sigh apneas during sleep and increases the ventilatory response to hypercapnia in adult female mice.

Despite an apparent trend, the difference in apnea frequency between WT and PRKO mice was not significant in progesterone-treated mice (P = 0.16).

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However, closer examination of the data showed a clear trend of PRKO mice to have a high frequency of post-sigh apnea even after progesterone treatment ( Figure 6C ).

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