Genetic variants of EGF and VEGF predict prognosis of patients with advanced esophageal squamous cell carcinoma.

PLoS One · 2014 · PMC4063891 · PMID 24945674

Europe PMC DOI

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0.0580

closest p · 1.2× alpha

0.1360

boldest claim

The sentences

borderline significantP = 0.058so close (0.05 < p ≤ 0.1)

EGFR:rs2227983 and 3 SNPs of PIK3CA also showed borderline significant correlation with OS of advanced ESCC patients (P = 0.058 for rs2227983; P = 0.069, 0.091 and 0.067 for rs6443624, rs7651265 and rs7621329 of PIK3CA respectively).

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borderline significanceP = 0.058so close (0.05 < p ≤ 0.1)

Even though none of these genetic polymorphisms significantly predicted tumor recurrence among these patients, EGFR:rs2227983, VEGF:rs2010963, and EGF:rs2237051 showed borderline significance for disease progression (P = 0.058 for EGFR:rs2227983, P = 0.073 for VEGF:rs2010963, and P = 0.104 for EGF:rs2237051; Table 2 ).

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showed a trendP = 0.136not close (p > 0.1)

As expected, homozygous GG carriers of rs4444903 showed a trend of increased EGF level compared with AA carriers ( Fig. 2A, T -test P = 0.136).

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