Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment.

Genome Med · 2014 · PMC4064311 · PMID 24571673

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nominally significantno p-value reported

In order to increase statistical power, we also analyzed the 158 genes for nominally significant associations in the original GWAS data from MS [ 52 ], comprising approximately 25,000 individuals.

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highly significantno p-value reported

The general relevance of this module was supported by highly significant enrichment of genetic variants identified by all GWAS and cancer studies, as well as known diagnostic and therapeutic targets.

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