Dose responsive effects of subcutaneous pentosan polysulfate injection in mucopolysaccharidosis type VI rats and comparison to oral treatment.

PLoS One · 2014 · PMC4071040 · PMID 24964042

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did not reach statistical significanceno p-value reported

Improvements in % bone volume/tissue volume (BV/TV), bone surface/volume ratio (BS/BV), trabecular number (Tb.N), trabecular separation (Tb.Sp), total porosity [Po(tot)], and bone mineral density (BMD) also were observed, although most of these values did not reach statistical significance (other than BMD in the 1 and 4 mg/kg groups).

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