A randomized study of recombinant GM-CSF (125 μg/m 2 daily for 14 consecutive days in 28-day cycles) versus placebo in patients with completely resected stage IIIB/IIIC/IV or mucosal melanoma, there was a trend toward improvement in DFS although it did not reach statistical significance (11.5 vs 9.2 months; HR, 0.88; P = 0.14), and no improvement in overall survival (OS; 69.6 vs 62.4 months; HR, 0.96; P = 0.78) [ 40 ].
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Current status of granulocyte-macrophage colony-stimulating factor in the immunotherapy of melanoma.
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