Local transformations of androgens into estradiol by aromatase P450 is involved in the regulation of prolactin and the proliferation of pituitary prolactin-positive cells.

In the present study, after in vivo treatment with the aromatase antagonist fadrozole, highly significant changes were observed in pituitary prolactin-positive cells: decreases in the intensity of the immunohistochemical cytoplasmic reaction, decreases in the percentage and proliferation of prolactin-positive cells, and decreases in the cellular and nuclear areas, accompanied by lower levels of serum prolactin.

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Percentage of prolactin-positive cells The variations observed among the control cultures ( Figure 4a ) and those treated with fadrozole or testosterone alone ( Figure 4b ) did not reach statistical significance ( Figure 4e ).

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