Double-disk synergy test for detection of synergistic effect between antibiotics against nosocomial strains of staphylococcus aureus.

In contrast to our finding, in the study of Kaka et al ., adding rifampin to cotrimoxazole showed a trend toward antagonism in vitro ;[ 16 ] also, in the study of Harvey et al ., the rifampin-trimethoprim-sulfamethoxazole combination was antagonistic in vitro against S. aureus .[ 17 ] Therefore, the efficacy of such antibiotic combinations should be evaluated in clinical trials.

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