Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke.

Exp Transl Stroke Med · 2014 · PMC4079187 · PMID 24991402

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a strong trendno p-value reported

While the chloroquine treated brains do not have a statistically significant increase in LC3II, there is a strong trend supporting high autophagic flux, and importantly this is not abrogated by flux inhibition.

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