AAV6|a-Syn animals displayed a significantly lower locomotor activity relative to AAV6|GFP (p<0.05) with a strong trend relative to intact Ctrls, indicating a desensitization of dopaminergic striatal receptors or loss of postsynaptic neuronal targets at 6 months with indications of dysregulation already at 8 weeks ( Fig. 1 A–B ).
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Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.
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