By t test, there was a statistically significant improvement of anti-inflammatory effect of targeted anti-PECAM vs control IgG coated NPs for E-selectin ( p = 0.029) and IL-8 ( p = 0.017) and a clear trend for VCAM (but not statistically significant, p = 0.057).
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Targeting to endothelial cells augments the protective effect of novel dual bioactive antioxidant/anti-inflammatory nanoparticles.
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