Little evidence for association between the TGFBR1*6A variant and colorectal cancer: a family-based association study on non-syndromic family members from Australia and Spain.

Results We report a finding of a nominally significant result using the pedigree-based association test approach (PBAT; p = 0.028), while other family-based tests were non-significant, but with a p-value <; 0.10 in each instance.

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One of the included studies genotyped rs11466445 in a Spanish cohort somewhat enriched for familial cancer, with ~15% of cases having an affected first-degree relative and found it to be borderline significant with diagnosis of CRC (p = 0.0491; 515 cases, 515 controls) [ 5 ].

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