Dendritic cell-secreted lipocalin2 induces CD8+ T-cell apoptosis, contributes to T-cell priming and leads to a TH1 phenotype.

In vitro intracellular staining for granzyme B and perforin of OT-I T-cells co-cultured with WT or Lcn2 −/− DCs showed a trend not statistically relevant ( figure 3C ), indicating that LCN2 probably does not affect the cytotoxic ability of CD8 + T-cells.

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