Intraperitoneal administration of a tumor-associated antigen SART3, CD40L, and GM-CSF gene-loaded polyplex micelle elicits a vaccine effect in mouse tumor models.

Compared with CD4 + cell depletion, double depletion of CD4 + /CD8a + cells further shortened the survival (23 days, n = 7) with a marginal significance ( P <0.05), but there was no difference in CD8a + and CD4 + /CD8a + cell depletion groups ( P = 0.31).

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Tumor growth inhibition in groups (n = 5−7 in each group) treated with CD40L (0.92±0.28 g), SART3 (0.72±0.27 g), GM-CSF (0.60±0.40 g), CD40L+GM-CSF (0.69±0.49 g), SART3+GM-CSF (0.74±0.13 g), or SART3+CD40L (0.69±0.44 g) did not reach statistical significance compared with that in the mock control ( Fig. 2D: left panel).

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