10 In PROLOG study, a strong trend toward a diminished risk of bleeding was shown with reductions in weight-adjusted heparin dosing and early sheath removal. 11 Chew et al. in a meta analysis showed that the risk of ischemic end points was progressively reduced with increasing ACT levels, with no observed upper limit of efficacy.
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Activated clotting time level with weight based heparin dosing during percutaneous coronary intervention and its determinant factors.
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